Pharmacokinetic analyses of the individual blood and plasma radioactivity and plasma concentrations of naronapride and its major metabolites were conducted using a noncompartmental approach with the validated computer program WinNonlin version 5.
All personnel followed standard safety precautions as required by laboratory policies and procedures in consideration of Material Safety Data Sheets and other relevant safety information. Oxidation efficiency was evaluated on each day of sample combustion by analyzing a commercial radiolabeled standard, both directly in scintillation cocktail and by oxidation.
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